Methylfolate (5-MTHF)
The active, bioavailable form of folate (vitamin B9). Dr. Peter Attia recommends methylfolate over folic acid for patients with MTHFR gene variants who cannot efficiently convert synthetic folic acid. Supports methylation, cardiovascular health, and mood regulation.
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I recommend methylfolate — the active form — particularly for anyone with MTHFR variants who can't efficiently convert folic acid. This is a meaningful difference in bioavailability.